As long as a conspiracy card is face up in the command zone, its static abilities affect the game, and its triggered abilities may trigger
That's also the reason why casting Vines of Vastwood or Stave Off at an extraordinarily beneficial time is all that much better, and because they tend to be very low-costed, it's a very powerful effect as it is - imagine Mother of Runes would (in addition to it's already powerful effect of protecting up to all of your creatures, including itself) also threaten lethal damage to any opponent on the board, at any time
BPhillipYork: Yeah I really kind of like this, its not amazingly fast or good unless you generate read ahead, but every stage does useful things and if you have ways to recur it it gets nasty
However, for full customizationespecially if you want to include artwork, text, or game elementshaving access to a printer and design software is highly recommended